Pharmacology and Technologies of the Heart and Circulation (PROTECT)
PROTECT team researches and develops pharmacological strategies and technologies to reduce the consequences of cardiovascular events such as myocardial infarction, heart failure or cardiac arrest. This research is based on an integrated approach that evolves from cellular models to clinical evaluations and in-depth preclinical studies. This translational approach has led to several clinical trials and the transfer of innovations to the industrial sector.

Selected publications
Jendoubi A, de Roux Q, Cariou A, Taccone FS, Ghaleh B, Tissier R, Kohlhauer M, Mongardon N. Management of post-resuscitation vasoplegic shock: targets, strategies and outcomes.
Crit Care. 2025 Dec 12;30(1):30. doi: 10.1186/s13054-025-05794-w.Haidour N, Favre H, Mateo P, Reydet J, Bizé A, Sambin L, Dai J, Chiaroni PM, Ghaleh B, Pernot M, Tanter M, Papadacci C. Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs.
Nat Commun. 2025 Oct 28;16(1):9317. doi: 10.1038/s41467-025-64911-z. PMID: 41152260 Free PMC articleJoffre J, Radermacher P, Kallel H, Marangon I, Rutault A, Levy Y, Gaudet A, Sarton B, Kreitmann L, Bezu L, Vedrenne M, Maldiney T, Jouan Y, Benghanem S, Stiel L, Germain S, Bréchot N; ‘commission recherche translationnelle de la société de réanimation de langue française’. Vascular leakage during circulatory failure: physiopathology, impact and treatments.
Ann Intensive Care. 2025 Jun 6;15(1):79. doi: 10.1186/s13613-025-01474-8. PMID: 40473887; PMCID: PMC12141729.Abi Zeid Daou Y, Watanabe N, Lidouren F, Bois A, Faucher E, Huet H, Hutin A, Jendoubi A, Surenaud M, Hue S, Nadeau M, Perrotto S, Libardi M, Ghaleh B, Micheau P, Bruneval P, Cariou A, Kohlhauer M, Tissier R. Ultrafast Cooling With Total Liquid Ventilation Mitigates Early Inflammatory Response and Offers Neuroprotection in a Porcine Model of Cardiac Arrest.
J Am Heart Assoc. 2024 Aug 20;13(16):e035617. doi: 10.1161/JAHA.124.035617. Epub 2024 Aug 19.Bréchot N, Rutault A, Marangon I, Germain S. Blood endothelium transition and phenotypic plasticity: A key regulator of integrity/permeability in response to ischemia.
Semin Cell Dev Biol. 2024 Mar 1;155(Pt C):16-22. doi: 10.1016/j.semcdb.2023.07.004. Epub 2023 Jul 20. PMID: 37479554.Gallet R, Su JB, Corboz D, Chiaroni PM, Bizé A, Dai J, Panel M, Boucher P, Pallot G, Brehat J, Sambin L, Thery G, Mouri N, de Pommereau A, Denormandie P, Germain S, Lacampagne A, Teiger E, Marbán E, Ghaleh B. Three-vessel coronary infusion of cardiosphere-derived cells for the treatment of heart failure with preserved ejection fraction in a pre-clinical pig model.
Basic Res Cardiol. 2023 Jul 3;118(1):26. doi: 10.1007/s00395-023-00995-2.Lesimple A, Fritz C, Hutin A, Charbonney E, Savary D, Delisle S, Ouellet P, Bronchti G, Lidouren F, Piraino T, Beloncle F, Prouvez N, Broc A, Mercat A, Brochard L, Tissier R, Richard JC; CAVIAR (Cardiac Arrest, Ventilation International Association for Research) Group. A novel capnogram analysis to guide ventilation during cardiopulmonary resuscitation: clinical and experimental observations.
Crit Care. 2022 Sep 23;26(1):287. doi: 10.1186/s13054-022-04156-0.Liabotis A, Ardidie-Robouant C, Mailly P, Besbes S, Gutierrez C, Atlas Y, Muller L, Germain S, Monnot C. Angiopoietin-like 4-Induced 3D Capillary Morphogenesis Correlates to Stabilization of Endothelial Adherens Junctions and Restriction of VEGF-Induced Sprouting.
Biomedicines. 2022 Jan 18;10(2):206. doi: 10.3390/biomedicines10020206. PMID: 35203415; PMCID: PMC8869696.